Which of the following terms can best define the word "abode"?

The term "abode" is best defined by the word itself. It refers specifically to a place of residence or dwelling. This term emphasizes the concept of a home where someone lives, making it distinct from other terms that may imply a larger property or specific style of residence.

While "estate," "building," and "villa" all refer to places or structures related to living, they carry different connotations. An "estate" usually implies a larger property, possibly with extensive grounds, and may not focus on the idea of a home. A "building" is a general term for any constructed structure, lacking the nuance of being a place of living. A "villa" typically denotes a specific style of house, often associated with leisure or luxury, rather than just a dwelling in a more general sense.

Thus, using the word "abode" directly connects to the meaning of a home or residence, making it the best fit in this context.