What is the term for extreme tiredness or exhaustion?

Fatigue is a term that specifically refers to a state of extreme tiredness or exhaustion, often resulting from prolonged physical or mental activity. This condition can significantly impair a person's ability to function and perform tasks effectively. While weariness can also denote tiredness, it does not encompass the deeper level of exhaustion that fatigue implies. Overwork refers to the act of working too much, which can lead to fatigue but is not synonymous with it. Weakness typically refers to a lack of strength or energy, which may be a symptom of fatigue but does not capture the comprehensive nature of extreme tiredness. Therefore, fatigue serves as the most precise term when describing an overwhelming sense of tiredness that encompasses both physical and mental exhaustion.